Two years into the COVID-19 pandemic: lessons learned

SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

Genomics and epidemiology of the P. 1 SARS-CoV-2 lineage in Manaus, Brazil

NR Faria, TA Mellan, C Whittaker, IM Claro… - Science, 2021 - science.org
Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in
Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome …

[HTML][HTML] Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

WF Garcia-Beltran, EC Lam, KS Denis, AD Nitido… - Cell, 2021 - cell.com
Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2.
However, ongoing surveillance has revealed the emergence of variants harboring mutations …

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity

SMC Gobeil, K Janowska, S McDowell, K Mansouri… - Science, 2021 - science.org
INTRODUCTION Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) have been circulating worldwide since the beginning of the pandemic. Some are termed …

[HTML][HTML] Humoral immunity against SARS-CoV-2 and the impact on COVID-19 pathogenesis

E Lee, JE Oh - Molecules and cells, 2021 - Elsevier
It has been more than a year since severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) first emerged. Many studies have provided insights into the various aspects of the …

Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants

N Teruel, O Mailhot… - PLoS computational …, 2021 - journals.plos.org
The SARS-CoV-2 Spike protein needs to be in an open-state conformation to interact with
ACE2 to initiate viral entry. We utilise coarse-grained normal mode analysis to model the …

Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B. 1.1. 33 during the early pandemic phase in Brazil

PC Resende, E Delatorre, T Gräf, D Mir… - Frontiers in …, 2021 - frontiersin.org
A previous study demonstrates that most of severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2) Brazilian strains fell in three local clades that were introduced from Europe …

[HTML][HTML] Bam-readcount-rapid generation of basepair-resolution sequence metrics

A Khanna, DE Larson, SN Srivatsan, M Mosior… - ArXiv, 2021 - ncbi.nlm.nih.gov
Bam-readcount is a utility for generating low-level information about sequencing data at
specific nucleotide positions. Originally designed to help filter genomic mutation calls, the …

ViralFlow: a versatile automated workflow for SARS-CoV-2 genome assembly, lineage assignment, mutations and intrahost variant detection

FZ Dezordi, AMS Neto, TL Campos, PMC Jeronimo… - Viruses, 2022 - mdpi.com
The COVID-19 pandemic is driven by Severe Acute Respiratory Syndrome coronavirus 2
(SARS-CoV-2) that emerged in 2019 and quickly spread worldwide. Genomic surveillance …

Genomic surveillance of SARS-CoV-2 tracks early interstate transmission of P. 1 lineage and diversification within P. 2 clade in Brazil

AP Lamarca, LGP de Almeida… - PLoS neglected …, 2021 - journals.plos.org
The sharp increase of COVID-19 cases in late 2020 has made Brazil the new epicenter of
the ongoing SARS-CoV-2 pandemic. The novel viral lineages P. 1 (Variant of Concern …