Vinpocetine attenuates thioacetamide-induced liver fibrosis in rats

AA Elnfarawy, AE Nashy, AM Abozaid… - Human & …, 2021 - journals.sagepub.com
Liver fibrosis is associated with increased mortality and morbidity. However, there is not
effective treatment so far. Vinpocetine (Vinpo) is a synthetic derivative of vinca alkaloid …

Resveratrol reduces gentamicin-induced EMT in the kidney via inhibition of reactive oxygen species and involving TGF-β/Smad pathway

ON Beshay, MG Ewees, MS Abdel-Bakky, SMNA Hafez… - Life Sciences, 2020 - Elsevier
Aims Gentamicin (GEN) is one of the most valuable aminoglycoside antibiotics utilized
against life-threatening bacterial infections. Unfortunately, GEN-induced nephrotoxicity …

Parthenolide phytosomes attenuated gentamicin-induced nephrotoxicity in rats via activation of Sirt-1, Nrf2, OH-1, and NQO1 axis

RS Albalawi, LS Binmahfouz, RH Hareeri, RA Shaik… - Molecules, 2023 - mdpi.com
Nephrotoxicity is a serious complication that limits the clinical use of gentamicin (GEN).
Parthenolide (PTL) is a sesquiterpene lactone derived from feverfew with various …

The Nephroprotective Effect of Zizyphus lotus L. (Desf.) Fruits in a Gentamicin-Induced Acute Kidney Injury Model in Rats: A Biochemical and Histopathological …

N Bencheikh, M Bouhrim, L Kharchoufa, OM Al Kamaly… - Molecules, 2021 - mdpi.com
Zizyphus lotus L.(Desf.)(Z. lotus) is a medicinal plant largely distributed all over the
Mediterranean basin and is traditionally used by Moroccan people to treat many illnesses …

Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken

SA Elgeddawy, HM Shaheen… - Journal of animal …, 2020 - Wiley Online Library
We evaluated the effect of prebiotic or probiotic as feed additives on florfenicol kinetic in
broilers feed. Unsexed two hundred, thirty‐five‐day‐old broiler chickens, were put in four …

Hepatoprotective effects of the xanthine oxidase inhibitor Febuxostat against thioacetamide-induced liver injury in rats: The role of the Nrf2/HO-1 and TLR4/NF-κB …

RS Abdelrahman, ME Abdelmageed - Food and Chemical Toxicology, 2024 - Elsevier
Experimental models of liver injury have been established utilizing thioacetamide (TAA), a
classic liver toxic chemical that causes organ damage via oxidative stress and inflammatory …

Psidium guajava L.: Chemical composition and protective effects of a leaf extract against ethanol-induced cardiotoxicity

AE Sherif, Y Amen, M Wink, M Sobeh… - South African Journal of …, 2023 - Elsevier
It has been previously reported that a leaf extract of Psidium guajava L.(GV. E) can impart
numerous health benefits that were attributed to its antioxidant and anti-inflammatory effects …

SB332235, a CXCR2 antagonist, ameliorates thioacetamide-induced hepatic encephalopathy through modulation of the PI3K/AKT pathways in rats

RR Abdelaziz, RS Abdelrahman, ME Abdelmageed - Neurotoxicology, 2022 - Elsevier
Highlights•SB protected against TAA-induced hepatic encephalopathy in rats.•SB decreased
serum NO, reduced hepatic and brain MDA, elevated GSH and SOD.•SB decreased brain …

Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B–induced renal injury: Down-regulation of NF-κB …

DM Abdel-Rahman, BAS Messiha, FEM Ali… - Naunyn-schmiedeberg's …, 2024 - Springer
Amphotericin B (AmB)–induced acute kidney injury (AKI) is a common health problem
having an undesirable impact on its urgent therapeutic utility for fatal systemic fungal …

Potential effects of Resatorvid and alpha lipoic acid on gentamicin‐induced nephrotoxicity in rats

B Dik, D Hatipoglu, MB Ates - Pharmacology Research & …, 2024 - Wiley Online Library
Gentamicin is an aminoglycoside antibiotic with a rapid bactericidal effect on the treatment of
many infections. However, its use at high concentrations for more than 7 days causes …