[HTML][HTML] A Review on Mitotane: A Target Therapy in Adrenocortical Carcinoma

F Flauto, MC De Martino, C Vitiello, R Pivonello… - Cancers, 2024 - mdpi.com
Adrenocortical carcinomas (ACCs) are rare and aggressive malignancies of adrenal cortex,
associated with largely unknown mechanisms of biological development and poor …

Roles and mechanisms of circular RNA in respiratory system cancers

N Yang, M Jiao, Y Zhang, S Mo, L Wang… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Circular RNAs (circRNAs) constitute a class of endogenous non-coding RNAs (ncRNAs) that
lack a 5'-ended cap and 3'-ended poly (A) tail and form a closed ring structure with covalent …

Fascin-1 expression is associated with neuroendocrine prostate cancer and directly suppressed by androgen receptor

A Turpin, C Delliaux, P Parent, H Chevalier… - British Journal of …, 2023 - nature.com
Background Neuroendocrine prostate cancer (NEPC) is an aggressive form of prostate
cancer, arising from resistance to androgen-deprivation therapies. However, the molecular …

ACTH and prolactin synergistically and selectively regulate CYP17 expression and adrenal androgen production in human foetal adrenal organ cultures

G Schneider, C Ruggiero, L Renault… - European Journal of …, 2023 - academic.oup.com
Objective The essential role of ACTH on the growth and function of the human foetal adrenal
(HFA) has long been recognized. In addition, many studies have suggested a role of the …

A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma

E Lalli - Frontiers in Endocrinology, 2023 - frontiersin.org
Background Overexpression of the transcription factor NR5A1 and constitutive activation of
canonical Wnt signalling leading to nuclear translocation of beta-catenin are hallmarks of …

The FSCN1 gene rs2966447 variant is associated with increased serum fascin-1 levels and breast cancer susceptibility

AR Abdullah, AMG El-Din, Y Ismail, AA El-Husseiny - Gene, 2024 - Elsevier
Abstract Fascin-1 (FSCN1) is recognized as an actin-binding protein, commonly exhibits up-
regulation in breast cancer (BC) and is crucial for tumor invasion and metastasis. The …

[HTML][HTML] Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma

E Luca, A Abate, K Wang, S Bornstein, S Sigala… - Endocrines, 2024 - mdpi.com
Adrenocortical carcinoma (ACC) and pheochromocytoma (PCC) are malignancies
originating from distinct layers of the adrenal gland. ACCs arise from the adrenal cortex, are …

N6‐methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16‐infected cervical squamous cell carcinoma

Q Tian, J Huang, Q Zhang… - Clinical and Experimental …, 2024 - Wiley Online Library
Human papillomavirus (HPV) infection has been reported to be associated with N6‐
methyladenosine (m6A) modification in cancers. However, the underlying mechanism by …

Radionuclide Treatment in Malignant Pheochromocytoma

F Dondi, F Bertagna - Primary Adrenal Malignancies, 2024 - Springer
Most metastatic pheochromocytomas and paragangliomas (mPPGLs) require systemic
therapy, and targeted radionuclide therapy is an efficient option in this setting. Low-specific …

Preclinic and Translational Research in Adrenal Malignancies

E Rapizzi, A Abate, M Tamburello, M Luconi… - Primary Adrenal …, 2024 - Springer
The heterogeneity of the adrenocortical carcinoma (ACC), pheochromocytoma and
paraganglioma cell phenotypes requires different experimental preclinical models to …