Active DNA demethylation: many roads lead to Rome

SC Wu, Y Zhang - Nature reviews Molecular cell biology, 2010 - nature.com
DNA methylation is one of the best-characterized epigenetic modifications and has been
implicated in numerous biological processes, including transposable element silencing …

Epigenetic reprogramming in mammals

HD Morgan, F Santos, K Green… - Human molecular …, 2005 - academic.oup.com
Epigenetic marking systems confer stability of gene expression during mammalian
development. Genome-wide epigenetic reprogramming occurs at stages when …

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

B Czermin, R Melfi, D McCabe, V Seitz, A Imhof… - Cell, 2002 - cell.com
Enhancer of Zeste is a Polycomb Group protein essential for the establishment and
maintenance of repression of homeotic and other genes. In the early embryo it is found in a …

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

JR Whetstine, A Nottke, F Lan, M Huarte, S Smolikov… - Cell, 2006 - cell.com
Histone methylation regulates chromatin structure, transcription, and epigenetic state of the
cell. Histone methylation is dynamically regulated by histone methylases and demethylases …

Epigenetic reprogramming during early development in mammals

F Santos, W Dean - Reproduction, 2004 - rep.bioscientifica.com
Epigenetic modifications serve as an extension of the information content by which the
underlying genetic code may be interpreted. These modifications mark genomic regions and …

Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment

MD Stewart, J Li, J Wong - Molecular and cellular biology, 2005 - Am Soc Microbiol
Abstract Histone H3 lysine 9 (H3-K9) methylation has been shown to correlate with
transcriptional repression and serve as a specific binding site for heterochromatin protein 1 …

[HTML][HTML] Dynamic chromatin modifications characterise the first cell cycle in mouse embryos

F Santos, AH Peters, AP Otte, W Reik, W Dean - Developmental biology, 2005 - Elsevier
On fertilisation, gametes undergo epigenetic reorganisation and re-establish totipotency.
Here, we investigate links between chromatin remodelling and asymmetric maintenance of …

Plasmodium falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors

C Flueck, R Bartfai, J Volz, I Niederwieser… - PLoS …, 2009 - journals.plos.org
Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The
malaria parasite Plasmodium falciparum employs antigenic variation of the major surface …

MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing

CV Andreu-Vieyra, R Chen, JE Agno, S Glaser… - PLoS …, 2010 - journals.plos.org
During gametogenesis and pre-implantation development, the mammalian epigenome is
reprogrammed to establish pluripotency in the epiblast. Here we show that the histone 3 …

Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana

JP Jackson, L Johnson, Z Jasencakova, X Zhang… - Chromosoma, 2004 - Springer
The Arabidopsis KRYPTONITE gene encodes a member of the Su (var) 3-9 family of histone
methyltransferases. Mutations of kryptonite cause a reduction of methylated histone H3 …