The asymmetric cell division of stem cells, which produces one stem cell and one
differentiating cell, has emerged as a mechanism to balance stem cell self-renewal and …

Microtubules are cytoskeletal filaments essential for numerous aspects of cell physiology.
They are polarized polymeric tubes with a fast growing plus end and a slow growing minus …

ASPM (known as Asp in fly and ASPM-1 in worm) is a microcephaly-associated protein
family that regulates spindle architecture, but the underlying mechanism is poorly …

Next-generation sequencing has greatly accelerated the discovery of rare human genetic
diseases. Nearly 45% of patients have variants associated with known diseases but the …

Recent advances in genome engineering are starting a revolution in biological research and
translational applications. The clustered regularly interspaced short palindromic repeats …

The microtubule cytoskeleton regulates cell polarity by spatially organizing membrane
trafficking and signaling processes. In epithelial cells, microtubules form parallel arrays …

Microtubule organization has a crucial role in regulating cell architecture. The geometry of
microtubule arrays strongly depends on the distribution of sites responsible for microtubule …

Centrioles play a key role in the development of the fly. They are needed for the correct
formation of centrosomes, the organelles at the poles of the spindle that can persist as …

Primary microcephaly (MCPH), is a neurological disorder characterized by small brain size
that results in numerous developmental problems, including intellectual disability, motor and …

Centrosome positioning is essential for their function. Typically, centrosomes are transported
to various cellular locations through the interaction of centrosomal microtubules (MTs) with …