DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

In this study, we investigate the interplay between Ku, a central non‐homologous end‐
joining component, and the Mre11–Rad50–Xrs2 (MRX) complex and Sae2, end‐processing …

The RecQ helicases are conserved from bacteria to humans and play a critical role in
genome stability. In humans, loss of RecQ gene function is associated with cancer …

DNA2 nuclease/helicase is a structure-specific nuclease, 5′-to-3′ helicase, and DNA-
dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki …

Homology-dependent repair of DNA double-strand breaks (DSBs) initiates by the 5′–3′
resection of the DNA ends to create single-stranded DNA (ssDNA), the substrate for …

DNA recombination pathways are regulated by the cell cycle to coordinate with replication.
Cyclin-dependent kinase (Cdk1) promotes efficient 5′ strand resection at DNA double …

Efficient and faithful replication of telomeric DNA is critical for maintaining genome integrity.
The G‐quadruplex (G4) structure arising in the repetitive TTAGGG sequence is thought to …

The long noncoding telomeric repeat containing RNA (TERRA) is expressed at chromosome
ends. TERRA upregulation upon experimental manipulation or in ICF (immunodeficiency …

The formation of single-stranded DNA (ssDNA) at double-strand break (DSB) ends is
essential in repair by homologous recombination and is mediated by DNA helicases and …