Recent scientific advances have significantly contributed to our understanding of the
complex connection between the microbiome and cancer. Our bodies are continuously …

Intestines are organs that not only digest food and absorb nutrients, but also provide a
defense barrier against pathogens and noxious agents ingested. Tight junctions (TJs) are …

Aging is characterized by a growing risk of disease and death, yet the underlying
pathophysiology is poorly understood. Indeed, little is known about how the functional …

The gut barrier plays an important role in human health. When barrier function is impaired,
altered permeability and barrier dysfunction can occur, leading to inflammatory bowel …

Obesity is a growing pandemic, and related health and economic costs are staggering.
Pharmacotherapy, partnered with lifestyle modifications, forms the core of current strategies …

Current studies of human gut microbiome usually do not consider the special functional role
of transient microbiota, although some of its members remain in the host for a long time and …

Abstract Polymorphisms of interleukin (IL)-23R and signaling components are associated
with several autoimmune diseases, including inflammatory bowel diseases (IBD). Similar to …

Functional gastrointestinal disorders (FGIDs) and IBDs are two of the most prevalent
disorders of the GI tract and consume a significant proportion of healthcare resources …

Purpose: Gastrointestinal cancers remain areas of high unmet need despite advances in
targeted and immunotherapies. Here, we demonstrate potent, tumor-selective efficacy with …

Gut homeostasis plays an important role in maintaining the overall body health during aging.
Rapamycin, a specific inhibitor of mTOR, exerts prolongevity effects in evolutionarily diverse …