In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked
during bone growth and regeneration in bone modeling and during bone homeostasis in …

During nervous system development, neurons extend axons to reach their targets and form
functional circuits. The faulty assembly or disintegration of such circuits results in disorders …

Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is
best known for mediating axon repulsion in the developing nervous system. However, in …

The corticospinal tract (CST) plays a major role in cortical control of spinal cord activity. In
particular, it is the principal motor pathway for voluntary movements. Here, we discuss:(i) the …

Blood vessels and nerve fibres course throughout the body in an orderly pattern, often
alongside one another. Although superficially distinct, the mechanisms involved in wiring …

Biomolecule gradients have been shown to play roles in a wide range of biological
processes including development, inflammation, wound healing, and cancer metastasis …

Endothelial cells (ECs) form extensive, highly branched and hierarchically organized tubular
networks in vertebrates to ensure the proper distribution of molecular and cellular cargo in …

The angiogenic sprout has been compared to the growing axon, and indeed, many proteins
direct pathfinding by both structures. The Roundabout (Robo) proteins are guidance …

Commissural axons in vertebrates and insects are initially attracted to the nervous system
midline, but once they reach this intermediate target they undergo a dramatic switch …

The explosion in sequencing technologies has provided us with an instrument to describe
mammalian transcriptomes at unprecedented depths. This has revealed that alternative …