Cholangiocarcinoma (CCA) is a highly lethal adenocarcinoma of the hepatobiliary system,
which can be classified as intrahepatic, perihilar and distal. Each anatomic subtype has …

Altered tissue mechanics and metabolism are defining characteristics of cancer that impact
not only proliferation but also migration. While migrating through a mechanically and …

Simple Summary The detection of colorectal cancer (CRC) at an early stage is increasing
due to the implementation of screening programs. Local excision of early CRC is potentially …

Glycans are one of the fundamental classes of macromolecules and are involved in a broad
range of biological phenomena. A large variety of glycan structures can be synthesized …

N-glycosylation is an abundant post-translational modification of most cell-surface proteins.
N-glycans play a crucial role in cellular functions like protein folding, protein localization, cell …

Chimeric antigen receptor (CAR) T cell therapy has created a paradigm shift in the treatment
of hematologic malignancies but has not been as effective toward solid tumors. For such …

The quiescent/slow‐cycling state preserves the self‐renewal capacity of cancer stem cells
(CSCs) and leads to the therapy resistance of CSCs. The mechanisms maintaining CSCs …

The complexity and dynamics of the immensely heterogeneous glycoproteome of the
prostate cancer (PCa) tumor microenvironment remain incompletely mapped, a knowledge …

Cholangiocarcinoma (CCA) is a highly heterogeneous and metastatic malignancy with a
poor prognosis even after curative hepatectomy. Studies exploring its pathogenesis and …

Background Cell therapies for solid tumors are thwarted by the hostile tumor
microenvironment (TME) and by heterogeneous expression of tumor target antigens. We …