Abstract 293 cell line (widely known as the Human Embryonic Kidney 293 cells) and its
derivatives were the most used cells after HeLa in cell biology studies and after CHO in …

Cancer research has traditionally focused on the characterization of individual molecular
mechanisms that can contribute to cancer. Due to the multiple levels of genomic and non …

Results of various cancer genome sequencing projects have “unexpectedly” challenged the
framework of the current somatic gene mutation theory of cancer. The prevalence of diverse …

Neoadjuvant and adjuvant therapies have made significant progress in cancer treatment.
However, tumor adjuvant therapy still faces challenges due to the intrinsic heterogeneity of …

Genome chaos, a process of complex, rapid genome re-organization, results in the
formation of chaotic genomes, which is followed by the potential to establish stable …

Over the last four decades, methodological innovations have continuously changed
transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs …

The basis for the gene mutation theory of cancer that dominates current molecular cancer
research consists of: the belief that gene‐level aberrations such as mutations are the main …

Cancer is traditionally labeled a “cellular growth problem.” However, it is fundamentally an
issue of macroevolution where new systems emerge from tissue by breaking various …

While the importance of chromosomal/nuclear variations vs. gene mutations in diseases is
becoming more appreciated, less is known about its genomic basis. Traditionally …

Mitochondrial fission and fusion cycles are integrated with cell cycle progression. Here we
first re-visited how mitochondrial ETC inhibition disturbed mitosis progression, resulting in …