Coenzyme Q (CoQ, ubiquinone) is the electron‐carrying lipid in the mitochondrial electron
transport system (ETS). In mammals, it serves as the electron acceptor for nine mitochondrial …

Mitochondria are small cellular constituents that generate cellular energy (ATP) by oxidative
phosphorylation (OXPHOS). Dysfunction of these organelles is linked to a heterogeneous …

Mitochondria play a critical role in bioenergetics, enabling stress adaptation, and therefore,
are central in biological stress responses and stress-related complex psychopathologies. To …

Neuropsychiatric disorders have complex pathophysiological constructs, requiring
translational models to improve our understanding thereof. Mitochondrial dysfunction …

Temperature shifts are a major challenge to animals; they drive adaptations in organisms
and species, and affect all physiological functions in ectothermic organisms. Understanding …

Objective: Early-life adversity (ELA) is one of the strongest predictors of childhood
depression that may be exacerbated by a genetic predisposition to develop depression. We …

Mitochondria are dynamic multitask organelles that function as hubs for many metabolic
pathways. They produce most ATP via the oxidative phosphorylation pathway, a critical …

Background Elevated plasma levels of alpha‐aminoadipic acid (2‐AAA) have been
associated with the development of type 2 diabetes and atherosclerosis. However, the …

Mitochondrial diseases (MD), such as Leigh syndrome (LS), present with severe
neurological and muscular phenotypes in patients, but have no known cure and limited …

Mitochondrial diseases, often caused by defects in complex I (CI) of the oxidative
phosphorylation system, currently lack curative treatments. Human-relevant, high-throughput …