Our insight into the diverse and complex nature of dilated cardiomyopathy (DCM) genetic
architecture continues to evolve rapidly. The foundations of DCM genetics rest on marked …

Efforts to implement and evaluate genome sequencing (GS) as a screening tool for
newborns and infants are expanding worldwide. The first iteration of the BabySeq Project …

We used a machine learning approach to analyze the within-gene distribution of missense
variants observed in hereditary conditions and cancer. When applied to 840 genes from the …

Asian populations are under-represented in human genomics research. Here, we
characterize clinically significant genetic variation in 9051 genomes representing East …

To understand the genetic contribution to primary pediatric cardiomyopathy, we performed
exome sequencing in a large cohort of 528 children with cardiomyopathy. Using clinical …

Importance Postmortem genetic testing of young individuals with sudden death has
previously identified pathogenic gene variants. However, prior studies primarily considered …

Aims Patient factors affect the risk of radiotherapy toxicity, but many are poorly defined.
Studies have shown that race affects cancer incidence, survival, drug response, molecular …

Background: Sequencing Mendelian arrhythmia genes in individuals without an indication
for arrhythmia genetic testing can identify carriers of pathogenic or likely pathogenic (P/LP) …

Genetic variation in genes regulating metabolism may be advantageous in some settings
but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and …

Objective Heritability of stroke is assumed not to be low, especially in the young stroke
population. However, most genetic studies have been performed in highly selected patients …