Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …

Genomic imprinting is a parent-of-origin dependent phenomenon that restricts transcription
to predominantly one parental allele. Since the discovery of the first long noncoding RNA …

Summary X-linked Dystonia-Parkinsonism (XDP) is a Mendelian neurodegenerative
disease that is endemic to the Philippines and is associated with a founder haplotype. We …

Phages express anti-CRISPR (Acr) proteins to inhibit CRISPR-Cas systems that would
otherwise destroy their genomes. Most acr genes are located adjacent to anti-CRISPR …

X-linked dystonia-parkinsonism (XDP) is a neurodegenerative disease associated with an
antisense insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of …

Synthetic genetic circuits offer the potential to wield computational control over biology, but
their complexity is limited by the accuracy of mathematical models. Here, we present …

Tandem transcription interference occurs when the act of transcription from an upstream
promoter suppresses utilization of a co-oriented downstream promoter. Because eukaryal …

More than 98% of the human genome does not encode proteins, and the vast majority of the
noncoding regions have not been well studied. Some of these regions contain enhancers …

Patterns of gene expression are primarily determined by proteins that locally enhance or
repress transcription. While many transcription factors target a restricted number of genes …

Long non-coding RNAs (lncRNAs) is a type of RNA over 200 nt long without any protein
coding ability, which has been investigated relating to crucial biological function in cells …