Defects in gastric progenitor cell differentiation are associated with various gastric disorders,
including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the …

A pervasive view is that undifferentiated stem cells are alone responsible for generating all
other cells and are the origins of cancer. However, emerging evidence demonstrates fully …

PDGFRA-expressing mesenchyme supports intestinal stem cells. Stomach epithelia have
related niche dependencies, but their enabling mesenchymal cell populations are unknown …

Chronic inflammation due to a Helicobacter pylori (H. pylori) infection is a representative
cause of gastric cancer that can promote gastric carcinogenesis by abnormally activating …

The glandular stomach is composed of two regenerative compartments termed corpus and
antrum, and our understanding of the transcriptional networks that maintain these tissues is …

In pyloric metaplasia, mature gastric chief cells reprogram via an evolutionarily conserved
process termed paligenosis to re-enter the cell cycle and become spasmolytic polypeptide …

Peptic ulcer disease caused by environmental factors increases the risk of developing
gastric cancer (GC), one of the most common and deadly cancers in the world. However, the …

Quiescent cancer stem cells (CSC) are resistant to conventional anticancer treatments and
have been shown to contribute to disease relapse after therapy in some cancer types. The …

Wnt signaling regulates gastric stem cell proliferation and differentiation. Although similar
Wnt gradients exist within the corpus and antrum of the human stomach, there are striking …

The stem/progenitor cell pool is indispensable for the development, homeostasis and
regeneration of the gastric epithelium, owing to its defining ability to self-renew whilst …