Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …

Self-maintaining resident macrophages populate all mammalian organs. In addition to their
role as immune sentinels, macrophages perform day-to-day functions essential to tissue …

Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues
and show great functional diversity. They have roles in development, homeostasis, tissue …

Mononuclear phagocyte plasticity includes the expression of functions related to the
resolution of inflammation, tissue repair and remodelling, particularly when these cells are …

Deleterious inflammation is a primary feature of breast cancer. Accumulating evidence
demonstrates that macrophages, the most abundant leukocyte population in mammary …

Introduction The immune system plays a major role in cancer progression. In solid tumors, 5-
40% of the tumor mass consists of tumor-associated macrophages (TAMs) and there is …

The cell-biological program termed the epithelial–mesenchymal transition (EMT) confers on
cancer cells mesenchymal traits and an ability to enter the cancer stem cell (CSC) state …

Stem cells regenerate tissues in homeostasis and under stress. By taking cues from their
microenvironment or" niche," they smoothly transition between these states. Immune cells …

Abstract Tumor-associated macrophages (TAMs), a crucial component of immune cells
infiltrated in tumor microenvironment, have been found to be associated with progression …

Macrophages are diverse immune cells that reside in all tissues. Although macrophages
have been implicated in mammary-gland function, their diversity has not been fully …