Both transcription and three-dimensional (3D) architecture of the mammalian genome play
critical roles in neurodevelopment and its disorders. However, 3D genome structures of …

SARS-CoV-2 infects less than 1% of cells in the human body, yet it can cause severe
damage in a variety of organs. Thus, deciphering the non-cell-autonomous effects of SARS …

Olfactory receptor (OR) choice provides an extreme example of allelic competition for
transcriptional dominance, where every olfactory neuron stably transcribes one of …

Stochastic cell fate specification, in which a cell chooses between two or more fates with a
set probability, diversifies cell subtypes in development. Although this is a vital process …

The cerebellum contains most of the neurons in the human brain and exhibits distinctive
modes of development and aging. In this work, by developing our single-cell three …

The simultaneous measurement of three-dimensional (3D) genome structure and gene
expression of individual cells is critical for understanding a genome's structure–function …

Sensory processing in olfactory systems is organized across olfactory bulb glomeruli,
wherein axons of peripheral sensory neurons expressing the same olfactory receptor co …

The sense of smell helps us navigate the environment, but its molecular architecture and
underlying logic remain understudied. The spatial location of odorant receptor genes (Olfrs) …

This Review elucidates the regulatory principles of random monoallelic expression by
focusing on two well-studied examples: the X-chromosome inactivation regulator Xist and …

Olfactory sensory neurons (OSNs) are functionally defined by their expression of a unique
odorant receptor (OR). Mechanisms underlying singular OR expression are well studied …