Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

The widely distributed TRPV4 cationic channel participates in the transduction of both
physical (osmotic, mechanical, and heat) and chemical (endogenous, plant-derived, and …

Mechanosensitivity is a well-known feature of astrocytes, however, its underlying
mechanisms and functional significance remain unclear. There is evidence that astrocytes …

Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-
coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the …

Cardiovascular diseases (CVD) are the leading cause of death in the world. However, due
to the limited effectiveness and potential adverse effects of current treatments, the long-term …

Transient receptor potential vanilloid 4 (TRPV4) is a non-selective mechanosensitive ion
channel expressed by various macrophage populations. Recent reports have characterized …

Transient receptor potential ankyrin repeat 1 (TRPA1) forms calcium (Ca 2+)-and zinc (Zn
2+)-permeable ion channels that sense noxious substances. Despite the biological and …

TRPV4 is associated with the development of neuropathic pain, sensory defects, muscular
dystrophies, neurodegenerative disorders, Charcot Marie Tooth and skeletal dysplasia. In all …

In several tissues, transient receptor potential vanilloid 4 (TRPV4) channels are involved in
the response to hyposmotic challenge. Here we report TRPV4 protein in porcine lens …

Evidence for a role for calcium channel proteins in cell proliferation is numerous suggesting
that calcium influx is essential in this physiological process. Several studies in the past thirty …