Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …
Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?
Alzheimer's disease (AD) is characterized by extracellular aggregates of amyloid β peptides,
intraneuronal tau aggregates, and neuronal death. This pathology triggers activation of …
intraneuronal tau aggregates, and neuronal death. This pathology triggers activation of …
[HTML][HTML] Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease
T Kamath, A Abdulraouf, SJ Burris, J Langlieb… - Nature …, 2022 - nature.com
The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain
A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues
into single-cell suspensions. While many protocols have been optimized for optimal cell …
into single-cell suspensions. While many protocols have been optimized for optimal cell …
[PDF][PDF] Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease
Resolving glial contributions to Alzheimer's disease (AD) is necessary because changes in
neuronal function, such as reduced synaptic density, altered electrophysiological properties …
neuronal function, such as reduced synaptic density, altered electrophysiological properties …
Four distinct trajectories of tau deposition identified in Alzheimer's disease
Alzheimer's disease (AD) is characterized by the spread of tau pathology throughout the
cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals …
cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals …
Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease
The gene-regulatory landscape of the brain is highly dynamic in health and disease,
coordinating a menagerie of biological processes across distinct cell types. Here, we …
coordinating a menagerie of biological processes across distinct cell types. Here, we …
Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease
Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes
that occur in specific cell types have not been fully characterized. Here, we profile single …
that occur in specific cell types have not been fully characterized. Here, we profile single …
[HTML][HTML] An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer's disease
V Lau, L Ramer, MÈ Tremblay - Nature Communications, 2023 - nature.com
Alzheimer's disease (AD) predominantly occurs as a late onset (LOAD) form involving
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …
Somatic genomic changes in single Alzheimer's disease neurons
Dementia in Alzheimer's disease progresses alongside neurodegeneration,,–, but the
specific events that cause neuronal dysfunction and death remain poorly understood. During …
specific events that cause neuronal dysfunction and death remain poorly understood. During …