Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

Acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 is largely the result of
a dysregulated host response, followed by damage to alveolar cells and lung fibrosis …

Single-cell RNA sequencing (scRNA-seq) enables the systematic identification of cell
populations in a tissue, but characterizing their spatial organization remains challenging. We …

NK cells are central to anti-tumor immunity and recently showed efficacy for treating
hematologic malignancies. However, their dysfunction in the hostile tumor microenvironment …

Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …

Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder that has been
diagnosed in an increasing number of children around the world. Existing data suggest that …

Nrf2 is a basic region leucine-zipper transcription factor that plays a pivotal role in the
coordinated gene expression of antioxidant and detoxifying enzymes, promoting cell …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …

The notion that electrophiles serve as messengers in cell signaling is now widely accepted.
Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as …