Activation, regulation, and inhibition of DYRK1A
Dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A) is a protein kinase
with diverse functions in neuronal development and adult brain physiology. Higher than …
with diverse functions in neuronal development and adult brain physiology. Higher than …
HMGA genes and proteins in development and evolution
R Vignali, S Marracci - International journal of molecular sciences, 2020 - mdpi.com
HMGA (high mobility group A)(HMGA1 and HMGA2) are small non-histone proteins that can
bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors …
bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors …
Intrinsic disorder and protein function
The dominant view of protein structure-function is that an amino acid sequence specifies a
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity
HMGA2 gene amplification and overexpression in human prolactinomas and the
development of pituitary adenomas in HMGA2 transgenic mice showed that HMGA2 plays a …
development of pituitary adenomas in HMGA2 transgenic mice showed that HMGA2 plays a …
[HTML][HTML] Deconstructing PML‐induced premature senescence
O Bischof, O Kirsh, M Pearson, K Itahana… - The EMBO …, 2002 - embopress.org
In this study, we investigated the subcellular and molecular mechanisms underlying
promyelocytic leu kemia (PML)‐induced premature senescence. We demonstrate that intact …
promyelocytic leu kemia (PML)‐induced premature senescence. We demonstrate that intact …
GATA-1-mediated proliferation arrest during erythroid maturation
M Rylski, JJ Welch, YY Chen, DL Letting… - … and cellular biology, 2003 - Am Soc Microbiol
Transcription factor GATA-1 is essential for erythroid and megakaryocytic maturation. GATA-
1 mutations are associated with hematopoietic precursor proliferation and leukemogenesis …
1 mutations are associated with hematopoietic precursor proliferation and leukemogenesis …
Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1
D D'Angelo, D Palmieri, P Mussnich… - The Journal of …, 2012 - academic.oup.com
Context: MicroRNA (miRNA) are an important class of regulators of gene expression. Altered
miRNA expression has been constantly found in human neoplasias and plays an important …
miRNA expression has been constantly found in human neoplasias and plays an important …
HMGA proteins as modulators of chromatin structure during transcriptional activation
High mobility group (HMG) proteins are the most abundant non-histone chromatin
associated proteins. HMG proteins bind to DNA and nucleosome and alter the structure of …
associated proteins. HMG proteins bind to DNA and nucleosome and alter the structure of …
The high mobility group A1 (HMGA1) transcriptome in cancer and development
TF Sumter, L Xian, T Huso, M Koo… - Current molecular …, 2016 - ingentaconnect.com
Background & Objectives: Chromatin structure is the single most important feature that
distinguishes a cancer cell from a normal cell histologically. Chromatin remodeling proteins …
distinguishes a cancer cell from a normal cell histologically. Chromatin remodeling proteins …
[HTML][HTML] HIPK2 in cancer biology and therapy: Recent findings and future perspectives
Homeodomain-interacting protein kinase 2 (HIPK2) is a serine-threonine kinase that
phosphorylates and regulates a plethora of transcriptional regulators and chromatin …
phosphorylates and regulates a plethora of transcriptional regulators and chromatin …