Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies

J Xie, Y Wang, W Choi, P Jangili, Y Ge, Y Xu… - Chemical Society …, 2021 - pubs.rsc.org
Photodynamic therapy (PDT) has been extensively investigated for decades for tumor
treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and …

[HTML][HTML] Gasdermin D in pyroptosis

BE Burdette, AN Esparza, H Zhu, S Wang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

Programmed cell death tunes tumor immunity

J Liu, M Hong, Y Li, D Chen, Y Wu, Y Hu - Frontiers in immunology, 2022 - frontiersin.org
The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19

JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
The rapid spread of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome–coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented …

NINJ1 mediates plasma membrane rupture during lytic cell death

N Kayagaki, OS Kornfeld, BL Lee, IB Stowe… - Nature, 2021 - nature.com
Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR
releases intracellular molecules known as damage-associated molecular patterns (DAMPs) …

The trinity of COVID-19: immunity, inflammation and intervention

MZ Tay, CM Poh, L Rénia, PA MacAry… - Nature Reviews …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into …

Apoptosis (programmed cell death) and its signals-A review

E Obeng - Brazilian Journal of Biology, 2020 - SciELO Brasil
Apoptosis is a sequential order of cell death occurring regularly to ensure a homeostatic
balance between the rate of cell formation and cell death. However, a misplaced of this …

The molecular virology of coronaviruses

E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …

The gasdermins, a protein family executing cell death and inflammation

P Broz, P Pelegrín, F Shao - Nature Reviews Immunology, 2020 - nature.com
The gasdermins are a family of recently identified pore-forming effector proteins that cause
membrane permeabilization and pyroptosis, a lytic pro-inflammatory type of cell death …

Understanding SARS-CoV-2-mediated inflammatory responses: from mechanisms to potential therapeutic tools

Y Fu, Y Cheng, Y Wu - Virologica Sinica, 2020 - Springer
Currently there is no effective antiviral therapy for SARS-CoV-2 infection, which frequently
leads to fatal inflammatory responses and acute lung injury. Here, we discuss the various …