Decellularization of natural tissues to produce extracellular matrix is a promising method for
three-dimensional scaffolding and for understanding microenvironment of the tissue of …

The immunologic barriers to successful xenotransplantation are related to the presence of
natural anti‐pig antibodies in humans and non‐human primates that bind to antigens …

Background The pig‐to‐non‐human primate model is the standard choice for in vivo studies
of organ and cell xenotransplantation. In 1998, Lambrigts and his colleagues surveyed the …

The main obstacle to successfully engineering corneal tissue has been the replication of the
structural and biochemical composition of native cornea in a scaffold. In recent years …

The search for alternatives to allotransplants is driven by the shortage of corneal donors and
is demanding because of the limitations of the alternatives. Indeed, current progress in …

Corneal transplantation is the only option to cure corneal opacities. However, there is an
imbalance between supply and demand of corneal tissues in the world. To solve the …

To address the shortcomings associated with corneal transplants, substantial efforts have
been focused on developing new modalities such as xenotransplantion. Xenogeneic …

The maintenance of corneal dehydration and transparency depends on barrier and pump
functions of corneal endothelial cells (CECs). The human CECs have no proliferation …

Approximately 39 million people are blind worldwide, with an estimated 285 million visually
impaired. The developing world shoulders 90% of the world's blindness, with 80% of …

The porcine cornea may be a good solution for the shortage of human donor corneas
because its size and refractive properties are comparable to those of the human cornea …