Group A Streptococcus (GAS; Streptococcus pyogenes) is a nearly ubiquitous human
pathogen responsible for a significant global disease burden. No vaccine exists, so …

In the ongoing conflict between eukaryotic cells and pathogens, lipid droplets (LDs) emerge
as a choke point in the battle for nutrients. While many pathogens seek the lipids stored in …

Rheumatic heart disease (RHD) is a serious and long-term consequence of acute rheumatic
fever (ARF), an autoimmune sequela of a mucosal infection by Streptococcus pyogenes …

Abstract Group A Streptococcus (GAS) is among the top ten causes of infection-related
mortality in humans. M protein is the most abundant GAS surface protein, and M1 serotype …

Neutrophils are innate immune cells that have a vital role in host defense systems.
Neutrophil extracellular traps (NETs) are one of neutrophils' defense mechanisms against …

SUMMARY Group A Streptococcus (GAS), also known as Streptococcus pyogenes, is a
clinically well-adapted human pathogen that harbors rich virulence determinants …

Microbes have developed many strategies to subvert host organisms, which, in turn, evolved
several innate immune responses. As major lipid storage organelles of eukaryotes, lipid …

Neutrophil extracellular traps (NETs) are considered part of the innate human immune
system because they are involved in host defense during bacterial infections. NETs are …

Neutrophils, as innate effector cells, play an essential role in the containment and
elimination of pathogens. Among the main neutrophil mechanisms use for these processes …

Staphylococcus aureus is a Gram-positive bacterium that can cause both superficial and
deep-seated infections. Histones released by neutrophils kill bacteria by binding to the …