Functions of adult-born neurons in hippocampal memory interference and indexing
SM Miller, A Sahay - Nature neuroscience, 2019 - nature.com
The dentate gyrus–CA3 circuit of the hippocampus is continuously modified by the
integration of adult-born dentate granule cells (abDGCs). All abDGCs undergo a prolonged …
integration of adult-born dentate granule cells (abDGCs). All abDGCs undergo a prolonged …
Functional optical probing of the hippocampal trisynaptic circuit in vitro: network dynamics, filter properties, and polysynaptic induction of CA1 LTP
J Stepan, J Dine, M Eder - Frontiers in neuroscience, 2015 - frontiersin.org
Decades of brain research have identified various parallel loops linking the hippocampus
with neocortical areas, enabling the acquisition of spatial and episodic memories. Especially …
with neocortical areas, enabling the acquisition of spatial and episodic memories. Especially …
Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice
The hippocampus is the brain's center for episodic memories. Its subregions, the dentate
gyrus and CA1-3, are differentially involved in memory encoding and recall. Hippocampal …
gyrus and CA1-3, are differentially involved in memory encoding and recall. Hippocampal …
On how the dentate gyrus contributes to memory discrimination
MT van Dijk, AA Fenton - Neuron, 2018 - cell.com
The dentate gyrus (DG) is crucial for behaviorally discriminating similar spatial memories,
predicting that DG place cells change (" remap") their relative spatial tuning (" place fields") …
predicting that DG place cells change (" remap") their relative spatial tuning (" place fields") …
Unit activity of hippocampal interneurons before spontaneous seizures in an animal model of temporal lobe epilepsy
I Toyoda, S Fujita, AK Thamattoor… - Journal of …, 2015 - Soc Neuroscience
Mechanisms of seizure initiation are unclear. To evaluate the possible roles of inhibitory
neurons, unit recordings were obtained in the dentate gyrus, CA3, CA1, and subiculum of …
neurons, unit recordings were obtained in the dentate gyrus, CA3, CA1, and subiculum of …
MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention
MYT1L is an autism spectrum disorder (ASD)-associated transcription factor that is
expressed in virtually all neurons throughout life. How MYT1L mutations cause neurological …
expressed in virtually all neurons throughout life. How MYT1L mutations cause neurological …
Elevation of hilar mossy cell activity suppresses hippocampal excitability and avoidance behavior
KY Wang, JW Wu, JK Cheng, CC Chen, WY Wong… - Cell Reports, 2021 - cell.com
Modulation of hippocampal dentate gyrus (DG) excitability regulates anxiety. In the DG,
glutamatergic mossy cells (MCs) receive the excitatory drive from principal granule cells …
glutamatergic mossy cells (MCs) receive the excitatory drive from principal granule cells …
Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome
Dravet syndrome (DS) is a neurodevelopmental disorder due to pathogenic variants in
SCN1A encoding the Nav1. 1 sodium channel subunit, characterized by treatment-resistant …
SCN1A encoding the Nav1. 1 sodium channel subunit, characterized by treatment-resistant …
Differential recruitment of dentate gyrus interneuron types by commissural versus perforant pathways
Gamma-aminobutyric acidergic (GABAergic) interneurons (INs) in the dentate gyrus (DG)
provide inhibitory control to granule cell (GC) activity and thus gate incoming signals to the …
provide inhibitory control to granule cell (GC) activity and thus gate incoming signals to the …
Multiple cannabinoid signaling cascades powerfully suppress recurrent excitation in the hippocampus
Recurrent excitatory neural networks are unstable. In the hippocampus, excitatory mossy
cells (MCs) receive strong excitatory inputs from dentate granule cells (GCs) and project …
cells (MCs) receive strong excitatory inputs from dentate granule cells (GCs) and project …