Tuberculosis (TB) chemotherapy started in the 1930s with the discovery by Domagk and
colleagues of the anti‐TB activity of sulfonamides. Since these compounds were very toxic …

ABSTRACT A total of 105 rifampin (RMP)-and/or isoniazid (INH)-resistant strains of
Mycobacterium tuberculosis isolated from different parts of Poland in 2000 were screened …

In this study, we describe a multiplex PCR to detect a AGC→ ACC (serine to threonine)
mutation in the katG gene and a− 15 C-to-T substitution (inhA C− 15T) at the 5′ end of a …

Pese a que la tuberculosis (TB) viene acompañando a la humanidad desde el neolítico,
ésta se mantiene como un serio problema de salud pública, agravado en los últimos años …

The frequency of resistance genotypes among Beijing and non-Beijing strains was
compared using a reverse blot hybridization assay to detect mutations within genes …

The present study investigated the prevalence and diagnostic potential of the most
commonly reported mutations associated with isoniazid resistance, katG 315Thr, katG …

Molecular characterization of the drug resistance of Mycobacterium tuberculosis strains with
different origins can generate information that is useful for developing molecular methods …

Bacterial chromosomal mutations that confer antibiotic resistance often have deleterious
effects that impose costs on reproductive fitness. This observation has led to the …

The number of multi-drug-resistant tuberculosis (MDR-TB) cases is rising worldwide. As a
countermeasure against this situation, the implementation of rapid molecular tests to identify …

In this study we designed two pairs of probes for the detection of rifampin and isoniazid
resistance in Mycobacterium tuberculosis with real-time PCR procedures. One pair of …