Activation of human endogenous retroviruses and its physiological consequences

N Dopkins, DF Nixon - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …

[HTML][HTML] Human endogenous retrovirus K (HML-2) in health and disease

B Xue, LA Sechi, DJ Kelvin - Frontiers in microbiology, 2020 - frontiersin.org
Human endogenous retroviruses (HERVs) are derived from exogenous retrovirus infections
in the evolution of primates and account for about 8% of the human genome. They were …

[HTML][HTML] Postmortem cortex samples identify distinct molecular subtypes of ALS: retrotransposon activation, oxidative stress, and activated glia

OH Tam, NV Rozhkov, R Shaw, D Kim, I Hubbard… - Cell reports, 2019 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive loss of motor neurons. While several pathogenic mutations have been …

Repetitive elements in aging and neurodegeneration

KE Copley, J Shorter - Trends in Genetics, 2023 - cell.com
Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …

[HTML][HTML] Diseases of the nERVous system: retrotransposon activity in neurodegenerative disease

OH Tam, LW Ostrow, M Gale Hammell - Mobile DNA, 2019 - Springer
Abstract Transposable Elements (TEs) are mobile genetic elements whose sequences
constitute nearly half of the human genome. Each TE copy can be present in hundreds to …

Association between Human Endogenous Retrovirus K gene expression and breast cancer

M Tourang, L Fang, Y Zhong… - Cellular, Molecular and …, 2021 - cmbr-journal.com
Breast cancer is one of the most common cancers known, and it is also a significant cause of
death in women. If breast cancer is diagnosed in the early stages of the disease and treated …

Human endogenous retrovirus K envelope in spinal fluid of amyotrophic lateral sclerosis is toxic

JP Steiner, M Bachani, N Malik, C DeMarino… - Annals of …, 2022 - Wiley Online Library
Objective Human endogenous retroviruses have been implicated in neurodegenerative
diseases including amyotrophic lateral sclerosis (ALS). Expression of human endogenous …

Safety and tolerability of Triumeq in amyotrophic lateral sclerosis: the Lighthouse trial

J Gold, DB Rowe, MC Kiernan, S Vucic… - … lateral sclerosis and …, 2019 - Taylor & Francis
Background: Neuroinflammation and human endogenous retroviruses (HERV) are thought
to have a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). Therapy …

[HTML][HTML] The landscape of hervRNAs transcribed from human endogenous retroviruses across human body sites

J She, M Du, Z Xu, Y Jin, Y Li, D Zhang, C Tao, J Chen… - Genome Biology, 2022 - Springer
Abstract Background Human endogenous retroviruses (HERVs), the remnants of ancient
retroviruses, account for 8% of the human genome, but most have lost their transcriptional …

[HTML][HTML] Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia

R Garza, Y Sharma, DAM Atacho, A Thiruvalluvan… - Cell Reports, 2023 - cell.com
Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a
robust, but poorly understood, neuroinflammatory response that contributes to the long-term …