Activation of human endogenous retroviruses and its physiological consequences
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …
human genome as remnants of ancient retroviral infections. These sequences became fixed …
[HTML][HTML] Human endogenous retrovirus K (HML-2) in health and disease
B Xue, LA Sechi, DJ Kelvin - Frontiers in microbiology, 2020 - frontiersin.org
Human endogenous retroviruses (HERVs) are derived from exogenous retrovirus infections
in the evolution of primates and account for about 8% of the human genome. They were …
in the evolution of primates and account for about 8% of the human genome. They were …
[HTML][HTML] Postmortem cortex samples identify distinct molecular subtypes of ALS: retrotransposon activation, oxidative stress, and activated glia
OH Tam, NV Rozhkov, R Shaw, D Kim, I Hubbard… - Cell reports, 2019 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive loss of motor neurons. While several pathogenic mutations have been …
the progressive loss of motor neurons. While several pathogenic mutations have been …
Repetitive elements in aging and neurodegeneration
KE Copley, J Shorter - Trends in Genetics, 2023 - cell.com
Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …
[HTML][HTML] Diseases of the nERVous system: retrotransposon activity in neurodegenerative disease
OH Tam, LW Ostrow, M Gale Hammell - Mobile DNA, 2019 - Springer
Abstract Transposable Elements (TEs) are mobile genetic elements whose sequences
constitute nearly half of the human genome. Each TE copy can be present in hundreds to …
constitute nearly half of the human genome. Each TE copy can be present in hundreds to …
Association between Human Endogenous Retrovirus K gene expression and breast cancer
M Tourang, L Fang, Y Zhong… - Cellular, Molecular and …, 2021 - cmbr-journal.com
Breast cancer is one of the most common cancers known, and it is also a significant cause of
death in women. If breast cancer is diagnosed in the early stages of the disease and treated …
death in women. If breast cancer is diagnosed in the early stages of the disease and treated …
Human endogenous retrovirus K envelope in spinal fluid of amyotrophic lateral sclerosis is toxic
JP Steiner, M Bachani, N Malik, C DeMarino… - Annals of …, 2022 - Wiley Online Library
Objective Human endogenous retroviruses have been implicated in neurodegenerative
diseases including amyotrophic lateral sclerosis (ALS). Expression of human endogenous …
diseases including amyotrophic lateral sclerosis (ALS). Expression of human endogenous …
Safety and tolerability of Triumeq in amyotrophic lateral sclerosis: the Lighthouse trial
Background: Neuroinflammation and human endogenous retroviruses (HERV) are thought
to have a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). Therapy …
to have a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). Therapy …
[HTML][HTML] The landscape of hervRNAs transcribed from human endogenous retroviruses across human body sites
J She, M Du, Z Xu, Y Jin, Y Li, D Zhang, C Tao, J Chen… - Genome Biology, 2022 - Springer
Abstract Background Human endogenous retroviruses (HERVs), the remnants of ancient
retroviruses, account for 8% of the human genome, but most have lost their transcriptional …
retroviruses, account for 8% of the human genome, but most have lost their transcriptional …
[HTML][HTML] Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia
Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a
robust, but poorly understood, neuroinflammatory response that contributes to the long-term …
robust, but poorly understood, neuroinflammatory response that contributes to the long-term …