Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models

S Couderq, M Leemans, JB Fini - Molecular and Cellular Endocrinology, 2020 - Elsevier
Thyroid hormones (THs) play critical roles in profound changes in many vertebrates, notably
in mammalian neurodevelopment, although the precise molecular mechanisms of these …

Toward an AOP network-based tiered testing strategy for the assessment of thyroid hormone disruption

D Knapen, E Stinckens, JE Cavallin… - Environmental …, 2020 - ACS Publications
A growing number of environmental pollutants are known to adversely affect the thyroid
hormone system, and major gaps have been identified in the tools available for the …

Evaluating thyroid hormone disruption: investigations of long-term neurodevelopmental effects in rats after perinatal exposure to perfluorohexane sulfonate (PFHxS)

L Ramhøj, U Hass, ME Gilbert, C Wood, T Svingen… - Scientific Reports, 2020 - nature.com
Thyroid hormones are critical for mammalian brain development. Thus, chemicals that can
affect thyroid hormone signaling during pregnancy are of great concern. Perfluorohexane …

A critical evaluation of thyroid hormone measurements in OECD test guideline studies: is there any added value?

M Beekhuijzen, JCW Rijk, M Meijer, MA de Raaf… - Reproductive …, 2019 - Elsevier
Recently several OECD test guidelines were updated to include thyroid hormone
measurements for assessing endocrine disruptor potency, which led to an imperative need …

Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening

C Deisenroth, VY Soldatow, J Ford… - Toxicological …, 2020 - academic.oup.com
Thyroid hormones (TH) are essential for regulating a number of diverse physiological
processes required for normal growth, development, and metabolism. The US EPA …

Boscalid shows increased thyroxin‐glucuronidation in rat but not in human hepatocytes in vitro

C Wiemann, S Melching‐Kollmuss… - Journal of Applied …, 2023 - Wiley Online Library
The fungicide boscalid induces thyroid histopathological and hormone effects in the rat,
secondary to liver enzyme induction. To assess the human relevance of liver enzyme …

[HTML][HTML] Overview of sources, fate, and Impact of Endocrine Disrupting Compounds in environment and assessment of their Regulatory Policies across different …

A Singh, G Singh, P Singh, VK Mishra - Total Environment Research …, 2023 - Elsevier
Under the present research we have reviewed the sources, fate of Endocrine Disrupting
Compounds (EDCs) and its impact on the health of both human and the environment …

The urgency for optimization and harmonization of thyroid hormone analyses and their interpretation in developmental and reproductive toxicology studies

M Beekhuijzen, S Schneider, N Barraclough… - Reproductive …, 2018 - Elsevier
In recent years several OECD test guidelines have been updated and some will be updated
shortly with the requirement to measure thyroid hormone levels in the blood of mammalian …

Developmental toxicity of perfluorohexane sulfonate (PFHxS)-effects on the immune and thyroid hormone systems

L Ramhøj - 2018 - orbit.dtu.dk
Both the immune and the thyroid hormone systems are integral to human physiology and
health. They are also important for normal development from early in fetal life, but …