Ruthenium (II) polypyridyl complexes form a vast family of molecules characterized by their
finely tuned photochemical and photophysical properties. Their ability to undergo excited …

The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …

Cancer immunotherapies provide survival benefits in responding patients, but many patients
fail to respond. Identifying the biology of treatment response and resistance are a priority to …

Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that
favors cancer progression, therapy resistance and immune evasion. By single-cell RNA …

Inhibition of carbonic anhydrase (CA, EC 4.2. 1.1) was clinically exploited for decades, as
most modern diuretics were obtained considering as lead molecule acetazolamide, the …

Cancer development is a complex process that follows an intricate scenario with a dynamic
interplay of selective and adaptive steps and an extensive cast of molecules and signaling …

Hypoxia-inducible factors (HIFs) and the HIF-dependent cancer hallmarks angiogenesis and
metabolic rewiring are well-established drivers of breast cancer aggressiveness, therapy …

Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …

The pH in tumour cells and the tumour microenvironment has played important roles in
cancer development and treatment. It was thought that both the extracellular and …