Hepatorenal syndrome: pathophysiology, diagnosis, and management

DA Simonetto, P Gines, PS Kamath - bmj, 2020 - bmj.com
Hepatorenal syndrome (HRS), the extreme manifestation of renal impairment in patients with
cirrhosis, is characterized by reduction in renal blood flow and glomerular filtration rate …

[PDF][PDF] The use of rifaximin in patients with cirrhosis

P Caraceni, V Vargas, E Solà, C Alessandria… - …, 2021 - Wiley Online Library
Rifaximin is an oral nonsystemic antibiotic with minimal gastrointestinal absorption and
broad‐spectrum antibacterial activity covering both gram‐positive and gram‐negative …

[HTML][HTML] Sarcopenia in cirrhosis: Prospects for therapy targeted to gut microbiota

R Maslennikov, A Alieva, E Poluektova… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Decreased muscle mass and function, also known as sarcopenia, is common in patients
with cirrhosis and is associated with a poor prognosis. Although the pathogenesis of this …

[HTML][HTML] Early diagnosis and prevention of infections in cirrhosis

AV Kulkarni, M Premkumar, JP Arab… - Seminars in Liver …, 2022 - thieme-connect.com
Strategies to prevent infection and improve outcomes in patients with cirrhosis. HAV,
hepatitis A virus; HBV, hepatitis B virus; COVID-19, novel coronavirus disease 2019; NSBB …

Novel perspectives in the management of decompensated cirrhosis

M Bernardi, P Caraceni - Nature Reviews Gastroenterology & …, 2018 - nature.com
The current approaches to the management of patients with decompensated cirrhosis are
based on targeted strategies aimed at preventing or treating specific complications of the …

[HTML][HTML] The search for disease-modifying agents in decompensated cirrhosis: from drug repurposing to drug discovery

P Caraceni, JG Abraldes, P Ginès, PN Newsome… - Journal of …, 2021 - Elsevier
Patients with decompensated cirrhosis are currently managed through targeted strategies
aimed at preventing or treating specific complications. In contrast, a disease-modifying agent …

[HTML][HTML] Hepatorenal syndrome: Current concepts and future perspectives

CY Jung, JW Chang - Clinical and molecular hepatology, 2023 - ncbi.nlm.nih.gov
Hepatorenal syndrome (HRS), a progressive but potentially reversible deterioration of
kidney function, remains a major complication in patients with advanced cirrhosis, often …

Antibiotic prophylaxis to prevent spontaneous bacterial peritonitis in people with liver cirrhosis: a network meta‐analysis

O Komolafe, D Roberts, SC Freeman… - Cochrane database …, 2020 - cochranelibrary.com
Background Approximately 2.5% of all hospitalisations in people with liver cirrhosis are for
spontaneous bacterial peritonitis. Spontaneous bacterial peritonitis is associated with …

[HTML][HTML] Efficacy of norfloxacin prophylaxis to prevent spontaneous bacterial peritonitis: a systematic review and meta-analysis

MM Mücke, VT Mücke, C Graf… - Clinical and …, 2020 - journals.lww.com
METHODS: We searched PubMed, Embase, and the Cochrane Registry from inception to
May 2019 to identify randomized controlled trials of patients with liver cirrhosis that assessed …

Low-dose rifaximin prevents complications and improves survival in patients with decompensated liver cirrhosis

X Zeng, X Sheng, PQ Wang, HG Xin, YB Guo… - Hepatology …, 2021 - Springer
Background and aims Rifaximin has been recommended as a prophylactic drug for hepatic
encephalopathy (HE) and spontaneous bacterial peritonitis (SBP). This study aims to …