Liver fibrosis is the most important predictor of mortality in nonalcoholic fatty liver disease
(NAFLD). Quantitative risk of mortality by fibrosis stage has not been systematically …

Hepatocellular carcinoma (HCC) is associated with chronic inflammation and fibrosis arising
from different etiologies, including hepatitis B and C and alcoholic and nonalcoholic fatty …

The mitogen-activated protein kinase (MAPK) signaling pathway is the primary regulatory
module of various cellular processes such as cell proliferation, differentiation, and stress …

Glucose metabolism reprogramming, which is a well‐established characteristic of multiple
cancers, demands a higher rate of glycolysis to meet the increasing demands for …

Ubiquitylation is a major posttranslational modification that controls most complex aspects of
cell physiology. It is reversed through the action of a large family of deubiquitylating …

Abstract Tumor Necrosis Factor alpha (TNFα, TNF) is a key mediator and regulator of
mammalian immune responses in healthy organisms and in diseased conditions. TNF …

Tumor‐associated neutrophils (TANs) play a crucial role in tumor development and
progression in the cancer microenvironment. Despite increased understanding of TAN …

Nuclear factor (NF)-κB transcription factors are pivotal regulators of innate and adaptive
immune responses, and perturbations of NF-κB signaling contribute to the pathogenesis of …

Polyubiquitination of proteins has a pivotal role in the regulation of numerous cellular
functions such as protein degradation, DNA repair and cell signaling. As deregulation of …

Hepatocyte death, inflammation, and liver fibrosis are the hallmarks of chronic liver disease.
Tumor necrosis factor-α (TNFα) is an inflammatory cytokine involved in liver inflammation …