Citrobacter rodentium is an extracellular enteric mouse-specific pathogen used to model
infections with human pathogenic Escherichia coli and inflammatory bowel disease. C …

Gasdermins (GSDMs) are a class of pore-forming proteins related to pyroptosis, a
programmed cell death pathway that is induced by a range of inflammatory stimuli. Small …

The guanylate binding protein (GBP) family of interferon‐inducible GTP ases promotes
antimicrobial immunity and cell death. During bacterial infection, multiple mouse Gbps …

The discovery of TMEM173/STING-dependent innate immunity has recently provided
guidance for the prevention and management of inflammatory disorders. Here, we show that …

Infections with many Gram-negative pathogens, including Escherichia coli, Salmonella,
Shigella, and Yersinia, rely on type III secretion system (T3SS) effectors. We hypothesized …

Pyroptosis is a newly discovered programmed cell death with inflammasome formation.
Pattern recognition receptors that identify repetitive motifs of prospective pathogens such as …

Inflammation is a part of the body's immune response for protection against pathogenic
infections and other cellular damages; however, chronic inflammation is a major cause of …

The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also
incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of …

Inhibition of inflammasome and pyroptotic pathways are promising strategies for clinical
treatment of autoimmune and inflammatory disorders. MCC950, a potent inhibitor of the NLR …

Inflammation is an immune response that protects against pathogens and cellular stress.
The hallmark of inflammatory responses is inflammasome activation in response to various …