Domesticated plants and animals played crucial roles as models for evolutionary change by
means of natural selection and for establishing the rules of inheritance, originally proposed …

Ever since the pre-molecular era, the birth of new genes with novel functions has been
considered to be a major contributor to adaptive evolutionary innovation. Here, I review the …

CTCF-binding locations represent regulatory sequences that are highly constrained over the
course of evolution. To gain insight into how these DNA elements are conserved and spread …

Systems biology requires comprehensive data at all molecular levels. Mass spectrometry
(MS)-based proteomics has emerged as a powerful and universal method for the global …

Parent-of-origin effects occur when the phenotypic effect of an allele depends on whether it
is inherited from the mother or the father. Several phenomena can cause parent-of-origin …

In a three-stage genome-wide association study among East Asian women including 22,780
cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer …

Gene regulation shapes the evolution of phenotypic diversity. We investigated the evolution
of liver promoters and enhancers in six primate species using ChIP-seq (H3K27ac and …

The discovery of genomic imprinting through studies of manipulated mouse embryos
indicated that the paternal genome has a major influence on placental development …

Background Transposable elements (TE) are an important source of evolutionary novelty in
gene regulation. However, the mechanisms by which TEs contribute to gene expression are …

Insulin-like growth factor 2 (IGF2) is an important growth factor, which promotes growth and
development in mammals during fetal and postnatal stages. Using CRISPR–Cas9 system …