Muscle wasting is a consequence of physiological changes or a pathology characterized by
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …

Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

The repair process of damaged tissue involves the coordinated activities of several cell
types in response to local and systemic signals. Following acute tissue injury, infiltrating …

Up to 50% of cancer patients suffer from a progressive atrophy of adipose tissue and
skeletal muscle, called cachexia, resulting in weight loss, a reduced quality of life, and a …

Skeletal muscle mass is subject to rapid changes according to growth stimuli inducing both
hypertrophy, through increased protein synthesis, and hyperplasia, activating the myogenic …

Macrophages play an essential role in the resolution of tissue damage through removal of
necrotic cells, thus paving the way for tissue regeneration. Macrophages also directly …

Skeletal muscle atrophy is defined as a decrease in muscle mass and it occurs when protein
degradation exceeds protein synthesis. Potential triggers of muscle wasting are long-term …

The pathophysiology of sepsis and septic shock involves complex cytokine and
inflammatory mediator networks. NF-κB activation is a central event leading to the activation …

The cytoplasmic events that control mammalian gene expression, primarily mRNA stability
and translation, potently influence the cellular response to internal and external signals. The …

Skeletal muscle atrophy/wasting is a serious complication of a wide range of diseases and
conditions such as aging, disuse, AIDS, chronic obstructive pulmonary disease, space …