Antibiotics are commonly used to fight against bacterial infections, but bacteria have already
been resistant to almost all antibiotics due to abuse of antibiotics. 1, 2, 4-Triazole derived …

Malaria, caused by protozoan parasites of the genus Plasmodium especially by the most
prevalent parasite Plasmodium falciparum, represents one of the most devastating and …

The novel coronavirus SARS-CoV-2 disease “COVID-19” emerged in China and rapidly
spread to other countries; due to its rapid worldwide spread, the WHO has declared this as a …

1.1. General Heterocyclic compounds, especially nitrogen heterocycles, are the most
important class of compounds in the pharmaceutical and agrochemical industries, with …

Highlights•Chloroquine is used for anti-malaria, anti-cancer and anti-virus treatment.•The
efficacy of hydroxychloroquine against COVID-19 is controversial.•Several quinoline …

α, β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in
medicinal chemistry, especially in the identification and development of potential anticancer …

Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually, including 875 million children in developing …

Quinoline (1-azanaphthalene) is a heterocyclic aromatic nitrogen compound characterized
by a double-ring structure that contains a benzene ring fused to pyridine at two adjacent …

Malaria remains a serious worldwide health danger and massive economic trouble to
disease-endemic nations. Presently, 250 million of malarial cases are expected worldwide …

Enables researchers to fully realize the potential to discover new pharmaceuticals among
heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this …