B cells are critical to immune homeostasis at mucosal surfaces including those of the
gastrointestinal tract. B cell-related abnormalities, comprising of a lympho-plasmacytic …

Background and aims Prenatal and early life bacterial colonisation is thought to play a major
role in shaping the immune system. Furthermore, accumulating evidence links early life …

As early commencement of inflammatory bowel disease (IBD) treatment has been shown to
substantially improve outcomes, it is of utmost importance to make a timely diagnosis of this …

Background BAFF production is increased in IBD patients. However, the specific role of
BAFF in IBD is still uncovered. This study aimed to investigate the expression and function of …

Background & Aims We aimed to identify biomarkers that might be used to predict responses
of patients with inflammatory bowel diseases (IBD) to vedolizumab therapy. Methods We …

Objective The ability to regulate B cell development has long been recognized to have
therapeutic potential in a variety of autoimmune diseases. However, despite the presence of …

Faecal calprotectin and faecal occult blood test (FOBT) were widely used in the diagnosis
and assessment of intestinal inflammation in inflammatory bowel disease (IBD). Recently we …

B cell activating factor (BAFF), a member of the tumor necrosis factor (TNF) family, plays a
critical role in the pathogenesis and progression of rheumatoid arthritis (RA). Chlorogenic …

B cell activating factor (BAFF) is essential for B cells to develop and respond to Ags.
Dysregulation of BAFF contributes to the development of some autoimmune diseases and …

The gastrointestinal tract is colonized by trillions of commensal microorganisms that
collectively form the microbiome and make essential contributions to organism homeostasis …