Addiction is a chronic relapsing disorder characterized by the loss of control over drug
intake, high motivation to obtain the drug, and a persistent craving for the drug …

The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …

Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic
dopaminergic pathway. Changes in DA mesolimbic neurotransmission have been found to …

Background The nucleus accumbens is a critical mediator of depression-related outcomes
to social defeat stress. Previous studies demonstrate distinct neuroplasticity adaptations in …

Although both men and women become addicted to drugs of abuse, women transition to
addiction faster, experience greater difficulties remaining abstinent, and relapse more often …

Maladaptive aggressive behaviour is associated with a number of neuropsychiatric
disorders and is thought to result partly from the inappropriate activation of brain reward …

The ventral striatum (nucleus accumbens) and its role in mood, reward, and motivation has
been the focus of significant research. Despite this interest, little work has addressed cell …

Drug-evoked synaptic plasticity in the mesolimbic system reshapes circuit function and
drives drug-adaptive behavior. Much research has focused on excitatory transmission in the …

The striatum has been involved in complex behaviors such as motor control, learning,
decision-making, reward and aversion. The striatum is mainly composed of medium spiny …

Over the last few decades, advances in human and animal‐based techniques have greatly
enhanced our understanding of the neural mechanisms underlying psychiatric disorders …