Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

Sphingosine-1-phosphate (S1P) is an important sphingolipid molecule involved in
regulating cardiovascular functions in physiological and pathological conditions by binding …

The role of phospholipid signaling in ovarian cancer is poorly understood. Sphingosine-1-
phosphate (S1P) is a bioactive metabolite of sphingosine that has been associated with …

Oxidative stress triggered by aging, radiation, or inflammation impairs ovarian function by
inducing granulosa cell (GC) apoptosis. However, the mechanism inducing GC apoptosis …

Signaling by the bioactive sphingolipid, sphingosine 1–phosphate (S1P), and its precursors
are emerging areas in pregnancy research. S1P and ceramide levels increase towards end …

As a fundamental aging mechanism, cellular senescence causes chronic inflammation via
the senescence‐associated secretory phenotype (SASP). Theca‐interstitial cells are an …

Background Chemotherapy is one of the causes of ovarian injury and infertility. Although
assisted reproductive technology helps young female patients with cancer become …

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid, noteworthy for its involvement
both in the modulation of various biological processes and in the development of many …

5-Fluorouracil (5-FU) is a common anti-tumor drug, but there is no effective treatment for its
side effect, intestinal mucositis. The inflammatory reaction of macrophages in intestinal …

Abstract Sphingosine-1-phoshate (S1P) is a membrane sphingolipid involved in several
physiological processes, including cell proliferation, tissue growth, cell survival and …