Most of us live blissfully unaware of the orchestrated function that our internal organs
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …

The bladder is innervated by extrinsic afferents that project into the dorsal horn of the spinal
cord, providing sensory input to the micturition centers within the central nervous system …

Disruptions to sensory pathways in the lower urinary tract commonly occur and can give rise
to lower urinary tract symptoms (LUTS). The unmet clinical need for treatment of LUTS has …

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a common chronic pelvic disorder with
sensory symptoms of urinary urgency, frequency, and pain, indicating a key role for …

Cross talk between the gastrointestinal tract and brain is of significant relevance for human
health and disease. However, our understanding of how the gut and brain communicate has …

While sensory and sympathetic neurons are known to innervate bone, previous studies have
found it difficult to unequivocally identify and characterize only those that are of sensory …

Non-muscle invasive bladder cancer (NMIBC) accounts for~ 70–75% of total bladder cancer
tumors and requires effective early intervention to avert progression. The cornerstone of high …

The recent surge in research on cannabinoids may have been fueled by changes in
legislation in several jurisdictions, and by approval for the use of cannabinoids for treatment …

Aim Bladder sensation is critical for coordinating voluntary micturition to maintain healthy
bladder function. Sensations are initiated by the activation of sensory afferents that innervate …

The bladder wall is innervated by a complex network of afferent nerves that detect bladder
stretch during filling. Sensory signals, generated in response to distension, are relayed to …