Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …

Objective To examine the traditional diet-heart hypothesis through recovery and analysis of
previously unpublished data from the Minnesota Coronary Experiment (MCE) and to put …

Linoleic acid (LA) is the most abundant polyunsaturated fatty acid found in the Western diet.
Cytochrome P450-derived LA metabolites 9, 10-epoxyoctadecenoic acid (9, 10-EpOME), 12 …

Topical capsaicin formulations are used for pain management. Safety and modest efficacy of
low-concentration capsaicin formulations, which require repeated daily self-administration …

Objective To determine whether dietary interventions that increase n-3 fatty acids with and
without reduction in n-6 linoleic acid can alter circulating lipid mediators implicated in …

Once viewed simply as a reservoir for carbon storage, lipids are no longer cast as
bystanders in the drama of biological systems. The emerging field of lipidomics is driven by …

When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

The capsaicin receptor, TRPV1, is regulated by phosphatidylinositol-4, 5-bisphosphate (PIP
2), although the precise nature of this effect (ie, positive or negative) remains controversial …

Paclitaxel-induced peripheral neuropathy is a common adverse effect during paclitaxel
treatment resulting in sensory abnormalities and neuropathic pain during chemotherapy and …