Arachidonic acid is metabolized by cyclooxygenase, lipoxygenase, and cytochrome P450
enzymes to produce prostaglandins, leukotrienes, epoxyeicosatrienoic acids (EETs), and …

Ischemic heart disease (IHD) is a major cause of cardiovascular morbidity and mortality
worldwide, which is characterized by an imbalance between cardiac oxygen supply and …

Aims Free fatty acid receptor 4 (Ffar4) is a G-protein-coupled receptor for endogenous
medium-/long-chain fatty acids that attenuates metabolic disease and inflammation …

The incidence of heart failure (HF) is generally preceded by cardiac hypertrophy (CH), which
is the enlargement of cardiac myocytes in response to stress. During CH, the metabolism of …

Numerous epidemiological studies have demonstrated that approximately 40% of
myocardial infarctions (MI) are associated with heart failure (HF). Resveratrol, a naturally …

The incidence, prevalence, and hospitalization rates associated with cardiovascular
diseases (CVDs) are projected to increase substantially in the world. Understanding of the …

Aims Investigate the involvement of 15-hydroxyeicosatetraenoic acid (15-HETE), an anti-
inflammatory molecule, on the beneficial effects of exercise therapy for osteoarthritis (OA) …

We had recently demonstrated that the racemic mixture of 19-hydroxyeicosatetraenoic acid
(19-HETE) protects against angiotensin II (Ang II)-induced cardiac hypertrophy. Therefore …

Numerous experimental studies have supported the evidence that 2-methoxyestradiol (2
ME) is a biologically active metabolite that mediates multiple effects on the cardiovascular …

Doxorubicin (DOX) has been reported to be a very potent and effective anticancer agent.
However, clinical treatment with DOX has been greatly limited due to its cardiotoxicity …