[HTML][HTML] Molecular mechanism of TRP channels

J Zheng - Comprehensive Physiology, 2013 - ncbi.nlm.nih.gov
Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of
physical and chemical stimuli. They are involved in the formation of sight, hearing, touch …

Inorganic polyphosphates as storage for and generator of metabolic energy in the extracellular matrix

WEG Müller, HC Schröder, X Wang - Chemical reviews, 2019 - ACS Publications
Inorganic polyphosphates (polyP) consist of linear chains of orthophosphate residues,
linked by high-energy phosphoanhydride bonds. They are evolutionarily old biopolymers …

Structure of the cold-and menthol-sensing ion channel TRPM8

Y Yin, M Wu, L Zubcevic, WF Borschel, GC Lander… - Science, 2018 - science.org
Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors that
are involved in a variety of physiological processes. Within the TRPM family, member 8 …

TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids

E Cao, JF Cordero-Morales, B Liu, F Qin, D Julius - Neuron, 2013 - cell.com
The capsaicin receptor, TRPV1, is regulated by phosphatidylinositol-4, 5-bisphosphate (PIP
2), although the precise nature of this effect (ie, positive or negative) remains controversial …

Inorganic polyphosphate, a multifunctional polyanionic protein scaffold

L Xie, U Jakob - Journal of Biological Chemistry, 2019 - ASBMB
Polyphosphate (polyP) consists of a linear arrangement of inorganic phosphates and defies
its structural simplicity with an astounding number of different activities in the cell. Already …

New insights in the formation of polyhydroxyalkanoate granules (carbonosomes) and novel functions of poly (3‐hydroxybutyrate)

D Jendrossek, D Pfeiffer - Environmental microbiology, 2014 - Wiley Online Library
The metabolism of polyhydroxybutyrate (PHB) and related polyhydroxyalkanoates (PHAs)
has been investigated by many groups for about three decades, and good progress was …

Protein polyphosphorylation of lysine residues by inorganic polyphosphate

C Azevedo, T Livermore, A Saiardi - Molecular cell, 2015 - cell.com
The complexity of higher organisms is not simply a reflection of the number of genes. A
network of additional regulatory features, including protein post-translational modifications …

Phosphoinositide regulation of TRP channels: A functional overview in the structural era

T Rohacs - Annual Review of Physiology, 2024 - annualreviews.org
Transient receptor potential (TRP) ion channels have diverse activation mechanisms
including physical stimuli, such as high or low temperatures, and a variety of intracellular …

Oxytocin modulates nociception as an agonist of pain-sensing TRPV1

Y Nersesyan, L Demirkhanyan, D Cabezas-Bratesco… - Cell reports, 2017 - cell.com
Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons
project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses …

Trafficking of thermoTRP channels

C Ferrandiz-Huertas, S Mathivanan, CJ Wolf, I Devesa… - Membranes, 2014 - mdpi.com
ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential
(TRP) channels that are activated by changes in the environmental temperature, from …