The fungal cell wall: structure, biosynthesis, and function

NAR Gow, JP Latge, CA Munro - Microbiology spectrum, 2017 - Am Soc Microbiol
The molecular composition of the cell wall is critical for the biology and ecology of each
fungal species. Fungal walls are composed of matrix components that are embedded and …

The antifungal pipeline: fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin

M Hoenigl, R Sprute, M Egger, A Arastehfar… - Drugs, 2021 - Springer
The epidemiology of invasive fungal infections is changing, with new populations at risk and
the emergence of resistance caused by the selective pressure from increased usage of …

Genetic control of Candida albicans biofilm development

JS Finkel, AP Mitchell - Nature Reviews Microbiology, 2011 - nature.com
Candida species cause frequent infections owing to their ability to form biofilms—surface-
associated microbial communities—primarily on implanted medical devices. Increasingly …

Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota

S Höfs, S Mogavero, B Hube - Journal of microbiology, 2016 - Springer
The interaction between Candida albicans and its host cells is characterized by a complex
interplay between the expression of fungal virulence factors, which results in adherence …

The evolution of drug resistance in clinical isolates of Candida albicans

CB Ford, JM Funt, D Abbey, L Issi, C Guiducci… - elife, 2015 - elifesciences.org
Candida albicans is both a member of the healthy human microbiome and a major pathogen
in immunocompromised individuals. Infections are typically treated with azole inhibitors of …

Candida glabrata: a review of its features and resistance

CF Rodrigues, S Silva, M Henriques - European journal of clinical …, 2014 - Springer
Candida species belong to the normal microbiota of the oral cavity and gastrointestinal and
vaginal tracts, and are responsible for several clinical manifestations, from mucocutaneous …

Adhesins in human fungal pathogens: glue with plenty of stick

PWJ de Groot, O Bader, AD de Boer, M Weig… - Eukaryotic …, 2013 - Am Soc Microbiol
Understanding the pathogenesis of an infectious disease is critical for developing new
methods to prevent infection and diagnose or cure disease. Adherence of microorganisms to …

A fungal immunotherapeutic vaccine (NDV-3A) for treatment of recurrent vulvovaginal candidiasis—a phase 2 randomized, double-blind, placebo-controlled trial

JE Edwards Jr, MM Schwartz… - Clinical Infectious …, 2018 - academic.oup.com
Background Recurrent vulvovaginal candidiasis (RVVC) is a problematic form of mucosal
Candida infection, characterized by repeated episodes per year. Candida albicans is the …

Flocculation, adhesion and biofilm formation in yeasts

KJ Verstrepen, FM Klis - Molecular microbiology, 2006 - Wiley Online Library
Yeast cells possess a remarkable capacity to adhere to abiotic surfaces, cells and tissues.
These adhesion properties are of medical and industrial relevance. Pathogenic yeasts such …

Th1-Th17 Cells Mediate Protective Adaptive Immunity against Staphylococcus aureus and Candida albicans Infection in Mice

L Lin, AS Ibrahim, X Xu, JM Farber, V Avanesian… - PLoS …, 2009 - journals.plos.org
We sought to define protective mechanisms of immunity to Staphylococcus aureus and
Candida albicans bloodstream infections in mice immunized with the recombinant N …