Macrolide antibiotics inhibit protein synthesis by targeting the bacterial ribosome. They bind
at the nascent peptide exit tunnel and partially occlude it. Thus, macrolides have been …

Macrolides represent a large family of protein synthesis inhibitors of great clinical interest
due to their applicability to human medicine. Macrolides are composed of a macrocyclic …

The quality of diffraction data obtained using silver and molybdenum microsources has been
compared for six model compounds with a wide range of absorption factors. The …

Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit
protein synthesis by binding within the exit tunnel of the bacterial ribosome. While these …

The ribosome is a ribonucleoprotein machine responsible for protein synthesis. In all
kingdoms of life it is composed of two subunits, each built on its own ribosomal RNA (rRNA) …

Macrolide resistance mechanisms can be target-based with a change in a 23S ribosomal
RNA (rRNA) residue or a mutation in ribosomal protein L4 or L22 affecting the ribosome's …

The 16-membered macrolide antibiotics (eg tylosin A and josamycin) are mainly used in
veterinary medicine, and are much less studied than their 14-and 15-membered …

In bacteria, transcription and translation take place in the same cellular compartment.
Therefore, a messenger RNA can be translated as it is being transcribed, a process known …

Ribosomes synthesizing proteins containing consecutive proline residues become stalled
and require rescue via the action of uniquely modified translation elongation factors, EF-P in …

Many antibiotics stop bacterial growth by inhibiting different steps of protein synthesis.
However, no specific inhibitors of translation termination are known. Proline-rich …