[HTML][HTML] The quest for multiscale brain modeling

E D'Angelo, V Jirsa - Trends in neurosciences, 2022 - cell.com
Addressing the multiscale organization of the brain, which is fundamental to the dynamic
repertoire of the organ, remains challenging. In principle, it should be possible to model …

On the nature and use of models in network neuroscience

DS Bassett, P Zurn, JI Gold - Nature Reviews Neuroscience, 2018 - nature.com
Network theory provides an intuitively appealing framework for studying relationships
among interconnected brain mechanisms and their relevance to behaviour. As the space of …

Macroscopic resting-state brain dynamics are best described by linear models

E Nozari, MA Bertolero, J Stiso, L Caciagli… - Nature biomedical …, 2024 - nature.com
It is typically assumed that large networks of neurons exhibit a large repertoire of nonlinear
behaviours. Here we challenge this assumption by leveraging mathematical models derived …

[HTML][HTML] Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology

F Maestú, W de Haan, MA Busche, J DeFelipe - Ageing Research Reviews, 2021 - Elsevier
Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

The connectomics of brain disorders

A Fornito, A Zalesky, M Breakspear - Nature Reviews Neuroscience, 2015 - nature.com
Pathological perturbations of the brain are rarely confined to a single locus; instead, they
often spread via axonal pathways to influence other regions. Patterns of such disease …

The dynamics of resting fluctuations in the brain: metastability and its dynamical cortical core

G Deco, ML Kringelbach, VK Jirsa, P Ritter - Scientific reports, 2017 - nature.com
In the human brain, spontaneous activity during resting state consists of rapid transitions
between functional network states over time but the underlying mechanisms are not …

Rethinking segregation and integration: contributions of whole-brain modelling

G Deco, G Tononi, M Boly… - Nature Reviews …, 2015 - nature.com
The brain regulates information flow by balancing the segregation and integration of
incoming stimuli to facilitate flexible cognition and behaviour. The topological features of …

Architectonic mapping of the human brain beyond Brodmann

K Amunts, K Zilles - Neuron, 2015 - cell.com
Brodmann has pioneered structural brain mapping. He considered functional and
pathological criteria for defining cortical areas in addition to cytoarchitecture. Starting from …

Activity flow over resting-state networks shapes cognitive task activations

MW Cole, T Ito, DS Bassett, DH Schultz - Nature neuroscience, 2016 - nature.com
Resting-state functional connectivity (FC) has helped reveal the intrinsic network
organization of the human brain, yet its relevance to cognitive task activations has been …

Advancing functional connectivity research from association to causation

AT Reid, DB Headley, RD Mill… - Nature …, 2019 - nature.com
Cognition and behavior emerge from brain network interactions, such that investigating
causal interactions should be central to the study of brain function. Approaches that …