[HTML][HTML] The quest for multiscale brain modeling
E D'Angelo, V Jirsa - Trends in neurosciences, 2022 - cell.com
Addressing the multiscale organization of the brain, which is fundamental to the dynamic
repertoire of the organ, remains challenging. In principle, it should be possible to model …
repertoire of the organ, remains challenging. In principle, it should be possible to model …
On the nature and use of models in network neuroscience
Network theory provides an intuitively appealing framework for studying relationships
among interconnected brain mechanisms and their relevance to behaviour. As the space of …
among interconnected brain mechanisms and their relevance to behaviour. As the space of …
Macroscopic resting-state brain dynamics are best described by linear models
It is typically assumed that large networks of neurons exhibit a large repertoire of nonlinear
behaviours. Here we challenge this assumption by leveraging mathematical models derived …
behaviours. Here we challenge this assumption by leveraging mathematical models derived …
[HTML][HTML] Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology
Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …
The connectomics of brain disorders
Pathological perturbations of the brain are rarely confined to a single locus; instead, they
often spread via axonal pathways to influence other regions. Patterns of such disease …
often spread via axonal pathways to influence other regions. Patterns of such disease …
The dynamics of resting fluctuations in the brain: metastability and its dynamical cortical core
In the human brain, spontaneous activity during resting state consists of rapid transitions
between functional network states over time but the underlying mechanisms are not …
between functional network states over time but the underlying mechanisms are not …
Rethinking segregation and integration: contributions of whole-brain modelling
The brain regulates information flow by balancing the segregation and integration of
incoming stimuli to facilitate flexible cognition and behaviour. The topological features of …
incoming stimuli to facilitate flexible cognition and behaviour. The topological features of …
Architectonic mapping of the human brain beyond Brodmann
K Amunts, K Zilles - Neuron, 2015 - cell.com
Brodmann has pioneered structural brain mapping. He considered functional and
pathological criteria for defining cortical areas in addition to cytoarchitecture. Starting from …
pathological criteria for defining cortical areas in addition to cytoarchitecture. Starting from …
Activity flow over resting-state networks shapes cognitive task activations
Resting-state functional connectivity (FC) has helped reveal the intrinsic network
organization of the human brain, yet its relevance to cognitive task activations has been …
organization of the human brain, yet its relevance to cognitive task activations has been …
Advancing functional connectivity research from association to causation
Cognition and behavior emerge from brain network interactions, such that investigating
causal interactions should be central to the study of brain function. Approaches that …
causal interactions should be central to the study of brain function. Approaches that …