Patterns and evolutionary consequences of pleiotropy
J Zhang - Annual Review of Ecology, Evolution, and Systematics, 2023 - annualreviews.org
Pleiotropy refers to the phenomenon of one gene or one mutation affecting multiple
phenotypic traits. While the concept of pleiotropy is as old as Mendelian genetics, functional …
phenotypic traits. While the concept of pleiotropy is as old as Mendelian genetics, functional …
Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation
W Han, L Liu, J Wang, H Wei, Y Li, L Zhang… - Nature Ecology & …, 2022 - nature.com
Contrary to classic theory prediction, sex-chromosome homomorphy is prevalent in the
animal kingdom but it is unclear how ancient homomorphic sex chromosomes avoid …
animal kingdom but it is unclear how ancient homomorphic sex chromosomes avoid …
Making sense of intralocus and interlocus sexual conflict
Sexual conflict occurs because males and females are exposed to different selection
pressures. This can affect many aspects of female and male biology, such as physiology …
pressures. This can affect many aspects of female and male biology, such as physiology …
[HTML][HTML] Genome-wide sexually antagonistic variants reveal long-standing constraints on sexual dimorphism in fruit flies
The evolution of sexual dimorphism is constrained by a shared genome, leading to 'sexual
antagonism', in which different alleles at given loci are favoured by selection in males and …
antagonism', in which different alleles at given loci are favoured by selection in males and …
The search for sexually antagonistic genes: Practical insights from studies of local adaptation and statistical genomics
Sexually antagonistic (SA) genetic variation—in which alleles favored in one sex are
disfavored in the other—is predicted to be common and has been documented in several …
disfavored in the other—is predicted to be common and has been documented in several …
[PDF][PDF] Natural variation at a single gene generates sexual antagonism across fitness components in Drosophila
Mutations with conflicting fitness effects in males and females accumulate in sexual
populations, reducing their adaptive capacity. 1, 2 Although quantitative genetic studies …
populations, reducing their adaptive capacity. 1, 2 Although quantitative genetic studies …
Species-specific partial gene duplication in Arabidopsis thaliana evolved novel phenotypic effects on morphological traits under strong positive selection
Gene duplication is increasingly recognized as an important mechanism for the origination
of new genes, as revealed by comparative genomic analysis. However, how new duplicate …
of new genes, as revealed by comparative genomic analysis. However, how new duplicate …
[HTML][HTML] A putative de novo evolved gene required for spermatid chromatin condensation in Drosophila melanogaster
EL Rivard, AG Ludwig, PH Patel, A Grandchamp… - PLoS …, 2021 - journals.plos.org
Comparative genomics has enabled the identification of genes that potentially evolved de
novo from non-coding sequences. Many such genes are expressed in male reproductive …
novo from non-coding sequences. Many such genes are expressed in male reproductive …
A de novo evolved gene in the house mouse regulates female pregnancy cycles
The de novo emergence of new genes has been well documented through genomic
analyses. However, a functional analysis, especially of very young protein-coding genes, is …
analyses. However, a functional analysis, especially of very young protein-coding genes, is …
HP6/Umbrea is dispensable for viability and fertility, suggesting essentiality of newly evolved genes is rare
S Grill, A Riley, M Selvaraj… - Proceedings of the …, 2023 - National Acad Sciences
The newly evolved gene Heterochromatin Protein 6 (HP6), which has been previously
classified as essential, challenged the dogma that functions required for viability are only …
classified as essential, challenged the dogma that functions required for viability are only …