Mitogen-activated protein kinase (MAPK) is a family of Ser/Thr protein kinases that are
widely distributed in eukaryotic cells. Studies in the last decade revealed that MAPK …

In mammals, the sperm activates the development of the egg by triggering a series of
oscillations in the cytosolic-free Ca 2+ concentration (Ca 2+ i). The sperm triggers these …

Fertilization is the process by which haploid gametes, sperm and egg, unite to produce a
genetically distinct individual. Interest in this area has exploded in recent years. Here are …

Production of functional eggs requires meiosis to be coordinated with developmental
signals. Oocytes arrest in prophase I to permit oocyte differentiation, and in most animals, a …

Reviews in Developmental Biology have covered the pathways that generate the all-
important intracellular calcium (Ca2+) signal at fertilization [Miyazaki, S., Shirakawa, H …

The mammalian egg appears to transduce the duration, amplitude, and temporal
presentation of the increase in the intracellular calcium concentration ([Ca2+] i) upon …

Although the dynamics of oscillations of cytosolic Ca2+ concentration ([Ca2+] cyt) play
important roles in early mammalian development, the impact of the duration when [Ca2+] cyt …

Fertilization in all species studied to date induces an increase in the intracellular
concentration of free calcium ions ([Ca2+] i) within the egg. In mammals, this [Ca2+] i signal …

Mammalian eggs arrest at metaphase of the second meiotic division (MetII). Sperm break
this arrest by inducing a series of Ca 2+ spikes that last for several hours. During this time …

[Frontiers in Bioscience S5, 451-477, January 1, 2013] Oocyte Maturation: A story of arrest and
release Aritro Sen1, Francesco C Page 1 [Frontiers in Bioscience S5, 451-477, January 1 …