[HTML][HTML] Role of lipid metabolism and signaling in mammalian oocyte maturation, quality, and acquisition of competence

R Khan, X Jiang, U Hameed, Q Shi - Frontiers in cell and …, 2021 - frontiersin.org
It has been found that the quality of oocytes from obese women has been compromised and
subsequent embryos displayed arrested development. The compromised quality may be …

[HTML][HTML] DOHaD: A Menagerie of Adaptations and Perspectives: The interplay between early embryo metabolism and mitoepigenetic programming of development

CB de Lima, EC Dos Santos, MA Sirard - Reproduction, 2023 - rep.bioscientifica.com
In brief This review discusses advances in the knowledge of epigenetic mechanisms
regulating mitochondrial DNA and the relationship with reproductive biology. Abstract …

[HTML][HTML] Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation

AS Pereyra, CT Lin, DM Sanchez, J Laskin… - Molecular …, 2022 - Elsevier
Objective Skeletal muscle is a heterogeneous and dynamic tissue that adapts to functional
demands and substrate availability by modulating muscle fiber size and type. The concept of …

Polymer lung surfactants attenuate direct lung injury in mice

DJ Fesenmeier, MV Suresh, S Kim, S Park… - ACS Biomaterials …, 2023 - ACS Publications
If not properly managed, acute lung injuries, either through direct or indirect causes, have
the potential to present serious risk for many patients worldwide. One of the mechanisms for …

[PDF][PDF] Lipid droplet dynamics regulate adult muscle stem cell fate

F Yue, SN Oprescu, J Qiu, L Gu, L Zhang, J Chen… - Cell reports, 2022 - cell.com
The lipid droplet (LD) is a central hub for fatty acid metabolism in cells. Here we define the
dynamics and explore the role of LDs in skeletal muscle satellite cells (SCs), a stem cell …

Multiple reaction monitoring profiling (MRM profiling): Small molecule exploratory analysis guided by chemical functionality

Z Xie, CR Ferreira, AA Virequ, RG Cooks - Chemistry and Physics of Lipids, 2021 - Elsevier
Small molecules, including metabolites and lipids, provide information on metabolic
pathways and active biological processes in living organisms. They are often diagnostic of …

Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel

KA LaFavers, E Macedo, PS Garimella… - Science translational …, 2019 - science.org
High serum concentrations of kidney-derived protein uromodulin [Tamm-Horsfall protein
(THP)] have recently been shown to be independently associated with low mortality in both …

Characterization and regulation of extracellular vesicles in the lumen of the ovine uterus

EV O'Neil, GW Burns, CR Ferreira… - Biology of …, 2020 - academic.oup.com
Secretions of the endometrium are vital for peri-implantation growth and development of the
sheep conceptus. Extracellular vesicles (EVs) are present in the uterine lumen, emanate …

[HTML][HTML] The dynamics between in vitro culture and metabolism: embryonic adaptation to environmental changes

CB de Lima, ÉC Dos Santos, J Ispada, PK Fontes… - Scientific Reports, 2020 - nature.com
Previous studies have discussed the importance of an optimal range of metabolic activity
during preimplantation development. To avoid factors than can trigger an undesirable …

[HTML][HTML] Multiomics analysis reveals the mechanical stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions

A Soundararajan, T Wang, R Sundararajan… - Frontiers in cell and …, 2022 - frontiersin.org
Trabecular meshwork (TM) tissue is subjected to constant mechanical stress due to the
ocular pulse created by the cardiac cycle. This brings about alterations in the membrane …