As brutally demonstrated by the COVID-19 pandemic, an effective immune system is
essential for survival. Developed over evolutionary time, viral nucleic acid detection is a …

Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the loss of
self-tolerance and formation of nuclear autoantigens and immune complexes resulting in …

The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune
activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by …

Successful pregnancy requires carefully-coordinated communications between the mother
and fetus. Immune cells and cytokine signaling pathways participate as mediators of these …

The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …

Objective Autoimmune encephalitis (AE) is an important and treatable cause of acute
encephalitis. Diagnosis of AE in a developing child is challenging because of overlap in …

Innate immunity against pathogens relies on an array of immune receptors to detect
molecular patterns that are characteristic of the pathogens, including receptors that are …