Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …

Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Background: Limb muscle dysfunction is prevalent in chronic obstructive pulmonary disease
(COPD) and it has important clinical implications, such as reduced exercise tolerance …

Growth hormone (GH) and insulin-like growth factor 1 (IGF1) are important regulators of
bone remodelling and metabolism and have an essential role in the achievement and …

Skeletal muscle is an essential tissue that attaches to bones and facilitates body
movements. Insulin-like growth factor-1 (IGF-1) is a hormone found in blood that plays an …

Myostatin, a member of the transforming growth factor-β superfamily, is a potent negative
regulator of skeletal muscle growth and is conserved in many species, from rodents to …

Skeletal muscle is the dominant organ system in locomotion and energy metabolism.
Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas …

Skeletal muscle atrophy is defined as a decrease in muscle mass and it occurs when protein
degradation exceeds protein synthesis. Potential triggers of muscle wasting are long-term …

About half of all cancer patients show a syndrome of cachexia, characterized by anorexia
and loss of adipose tissue and skeletal muscle mass. Cachexia can have a profound impact …

Myostatin is an extracellular cytokine mostly expressed in skeletal muscles and known to
play a crucial role in the negative regulation of muscle mass. Upon the binding to activin …