Early life adversity and neuropsychiatric disease: differential outcomes and translational relevance of rodent models

RC Waters, E Gould - Frontiers in systems neuroscience, 2022 - frontiersin.org
It is now well-established that early life adversity (ELA) predisposes individuals to develop
several neuropsychiatric conditions, including anxiety disorders, and major depressive …

Adolescent Nonpharmacological Interventions for Early-Life Stress and Their Mechanism

Y Li, DD Shi, Z Wang - Behavioural Brain Research, 2023 - Elsevier
Those with a negative experience of psychosocial stress during the early stage of life not
only have a high susceptibility of the psychiatric disorder in all phases of their life span, but …

Loss of spines in the prelimbic cortex is detrimental to working memory in mice with early-life adversity

L Xu, Y Liu, J Long, X He, F Xie, Q Yin, M Chen… - Molecular …, 2023 - nature.com
Adverse experiences in early life can shape neuronal structures and synaptic function in
multiple brain regions, leading to deficits of distinct cognitive functions later in life. Focusing …

A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences

BD Kangas, AK Short, OT Luc, HS Stern… - …, 2022 - nature.com
Exposure to early-life adversity (ELA) is associated with several neuropsychiatric conditions,
including major depressive disorder, yet causality is difficult to establish in humans. Recent …

Early resource scarcity alters motivation for natural rewards in a sex-and reinforcer-dependent manner

AV Williams, J Flowers, KS Coates, A Ingram… - …, 2022 - Springer
Rationale Early life adversity impacts reward-related behaviors, including reward seeking for
drugs of abuse. However, the effects of early stress on natural rewards, such as food and …

Sex-specific behavioral outcomes of early-life adversity and emerging microglia-dependent mechanisms

MM Garvin, JL Bolton - Frontiers in behavioral neuroscience, 2022 - frontiersin.org
Early-life adversity (ELA) is known to alter brain circuit maturation as well as increase
vulnerability to cognitive and emotional disorders. However, the importance of examining …

[HTML][HTML] Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress

M Rincón-Cortés - Addiction neuroscience, 2023 - Elsevier
In humans, exposure to early life stress (ELS) is an established risk factor for the
development of substance use disorders (SUDs) during later life. Similarly, rodents exposed …

Early adversity changes the economic conditions of mouse structural brain network organization

S Carozza, J Holmes, PE Vértes… - Developmental …, 2023 - Wiley Online Library
Early adversity can change educational, cognitive, and mental health outcomes. However,
the neural processes through which early adversity exerts these effects remain largely …

Early adversity changes the economic conditions of structural brain network organisation

S Carozza, J Holmes, PE Vértes, E Bullmore, TM Arefin… - BioRxiv, 2022 - biorxiv.org
Early adversity can change educational, cognitive, and mental health outcomes. However,
the neural processes through which early adversity exerts these effects remain largely …

History of “serve and return” and a synthesis of the literature on its impacts on children's health and development

J Komanchuk, N Letourneau… - Issues in Mental …, 2023 - Taylor & Francis
Parent/caregiver sensitivity and responsiveness are important for children's health and
development. The “serve and return” metaphor was created to help providers and caregivers …